Journal of Biological Sciences and Medicine https://jbscim.com/index.php/jbsm <p>The “<strong><em>Journal of Biological Sciences and Medicine</em></strong>” (JBSM) is an international open access journal in English published quarterly. The aim of JBSM is to publish rapid and peer reviewed original research articles, scientific reports, review and mini-reviews in the developing and interdisciplinary field of biological, environmental and medical sciences. We welcome original research papers covering all aspects of modern biology for publication in our journal. Aspiring young scientists, medical professionals and researchers especially in the field of biology, biomedicine, environmental sciences, agricultural sciences, forestry, biotechnology etc., are wholeheartedly encouraged to submit their valuable contributions.</p> <p>Journal of Biological Sciences and Medicine welcomes original, unpublished research papers which includes critical analysis of any aspect of all subjects from the faculty members, graduate students, independent researchers, and writers from all over the world. The scope of the journal is wide open to the International arena.</p> Journal of Biological Sciences and Medicine en-US Journal of Biological Sciences and Medicine 2455-5266 <p>Authors who publish with this journal agree to the following terms:</p> <ol> <li>Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a&nbsp;<a href="http://creativecommons.org/licenses/by/4.0">Creative Commons Attribution License</a>&nbsp;that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.</li> <li>Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.</li> <li>Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See&nbsp;<a href="http://opcit.eprints.org/oacitation-biblio.html" target="_new">The Effect of Open Access</a>).</li> </ol> Alpha tocopherol: Exploring the link with Oxidative stress, Smokeless tobacco and Periodontal Disease https://jbscim.com/index.php/jbsm/article/view/115 <p><strong>Background: </strong>Alpha tocopherol (vitamin E) is a radical-scavenging antioxidant that protect the cells from reactive oxygen species (ROS). Increased ROS production causes oxidative stress. The effects of smokeless tobacco on periodontal disease have fewer consideration. Taking this into concern the present study was designed to determine both saliva and serum alpha-tocopherol levels in periodontal health and disease. <strong>Materials and Methods: </strong>120 individuals of age 17 to 65 years were categorized into four groups as Group I: 30 healthy (H), group II: 30 chronic periodontitis (CP), group III: 30 smoker patients with CP, group IV: 30 smokeless tobacco chewers with CP. Vitamin E levels were determined by UV-spectrophotometer (536 nm). Statistical analysis was performed by using Analysis of variance (ANOVA) and Tukeys multiple post hoc comparison test. <strong>Results: </strong>Mean vitamin E levels in saliva and serum were found highest for Group I &amp; least in Group III. When intergroup comparison was done, the differences in the mean vitamin E concentrations in saliva were statistically significant in all except in between Group II and IV. Whereas mean serum levels were statistically significant in all except in between Group III and IV. <strong>Conclusion:</strong> Low salivary and serum level of α-tocopherol is indicative of oxidative stress associated with smoking and smokeless tobacco. &nbsp;</p> <p>&nbsp;</p> <p><strong>Keywords:</strong> Alpha tocopherol, oxidative stress, smokeless tobacco, smoking, chronic periodontitis.</p> Roma Kewlani Nagaraj B Kalburgi Arati C Koregol ##submission.copyrightStatement## http://creativecommons.org/licenses/by/4.0 2019-06-30 2019-06-30 5 2 Effect of systemically administered Ornidazole and Metronidazole with or without scaling and root planing: A clinical study https://jbscim.com/index.php/jbsm/article/view/130 <p style="text-align: justify;">The present study evaluates and compares the clinical effects of systemic metronidazole and ornidazole in sites with or without scaling and root planing (SRP) in generalized chronic periodontitis patients in terms of gingival scores(GS), Probing depth(PD) and Bleeding on probing(BOP). A total of 40 patients suffering from chronic periodontitis (18-42 years) were selected &amp; randomly divided equally into three groups on the basis of the treatment plan. The clinical parameters were assessed at baseline i.e. day 0, day 7 and day 14 post-treatment. Clinical parameters gingival inflammation, pocket depth and bleeding on probing over a period of 14 days Ornidazole + SRP proved to be a better mode of treatment. Significant improvement was noted in all the five treatment modalities in treating chronic generalized periodontitis.</p> Manisha Pathak Anand Kishore Awadhesh Kumar Singh ##submission.copyrightStatement## http://creativecommons.org/licenses/by/4.0 2019-07-01 2019-07-01 5 2 Use of microRNA therapy in Cancer treatment: A novel therapeutic approach https://jbscim.com/index.php/jbsm/article/view/117 <p>The study of a class of small non-coding RNA molecules, named microRNAs (mi RNAs), has advanced our understanding of many of the fundamental processes of cancer biology and the molecular mechanisms underlying tumor initiation and progression. Mi RNA research has become more and more attractive as evidence is emerging that mi RNAs likely play important regulatory roles virtually in all essential bioprocesses. Looking at this field over the past decade it becomes evident that our understanding of mi RNAs remains rather incomplete. As research continues to reveal the mechanisms underlying cancer therapy efficacy, it is clear that mi RNAs contribute to responses to drug therapy and are themselves modified by drug therapy. One important area for mi RNA research is to understand the functions of mi RNAs and the relevant signaling pathways in the initiation, progression and drug-resistance of tumors to be able to design novel, effective targeted therapeutics that directly target pathologically essential mi RNAs and/or their target genes. Another area of increasing importance is the use of mi RNA signatures in the diagnosis and prognosis of various types of cancers. As the study of non-coding RNAs is increasingly more popular and important, it is without doubt that the next several years of mi RNA research will provide more fascinating results.</p> Preeti Raperia ##submission.copyrightStatement## http://creativecommons.org/licenses/by/4.0 2019-06-30 2019-06-30 5 2