Tumor Suppressor Gene p53 (mt) Expression in Mancozeb treated Mouse Liver

  • Indu Chaturvedi Central Institute for Research on Goats, Mathura, Uttar Pradesh, India
  • Sita Ram Tripathi Janta College Bakewar affiliated to C.S.J.M.U. Kanpur


Many carcinogens were reported to induce mutation, a number of focal proliferative lesions and degenerative changes as well as carcinoma of multiple animal species. Mancozeb is a known fungicide. Many studies suggest it acts like a carcinogen. In our study, we want to know realty and harmful concentration of mancozeb. We gave different concentration treatments to swiss albino mice. Our finding says 100 mg per Kg body is harmful or may act like carcinogenic.


Barrett JC & Fletcher WF (1987) Cellular and molecular mechanisms of multi-step carcinogenesis in cell culture models. In Mechanisms of Environmental Carcinogenesis, Vol: 2, Multistep Models of Carcinogenesis. 73-116. Boca Raton, FL, USA: CRC Press

Chaturvedi I (2015) A Molecular Docking study to find Natural Inhibitor against FAT10 Protein for curing Hepatic Carcinoma. JOS. 1 (2):1-9

Chaturvedi I, Sinha S (2016) A molecular docking study to understand the interaction between anti-Cancerous compounds and 12bp DNA sequences: poly (dA-dT)12 and poly (dG-dC)12. JOS. 1 (4) 19-24

EPA Mancozeb Facts, U.S. Environmental Protection Agency, EPA 738-F-05-XX, September 2005, 1–3

Evanthia Diamanti-Kandarakis, Jean-Pierre Bourguignon L C, Giudice R H, Gail S. Prins, Ana M. Soto, R. Thomas Zoeller, and Andrea C. Gore (2009) Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement.Endocr Rev. 30(4):293–342

Harrison Brody A, Chou E, Gray JM, Pokyrwka NJ, Raley-Susman KM. (2013) Mancozeb-induced behavioral deficits precede structural neural degeneration. Neurotoxicology. 34:74-81

Murphy G.P, Walter Lawrence, Raymond E. Lenhard (1995) American Cancer Society textbook of clinical oncology. 2nd ed. 1995, Atlanta, Ga The Society. xii, 766-768 of plates

Oyen, M.L. and Materials Research Society. Spring Meeting, 2014 Advanced materials for biological and biomedical applications : symposium held April 1-5, 2013, San Francisco, California, U.S.A. Materials Research Society symposium proceedings. 201, Warrendale, Pa.New York, N.Y.: Materials Research Society; Cambridge University Press. xiii, 267

Shukla Y, Arora A (2001) Transplacental carcinogenic potential of the carbamate fungicide mancozeb. J Environ Pathol Toxicol Oncol. 20(2):127-31

Susan Elmore (2007) Apoptosis: A Review of Programmed Cell Death.Toxicol Pathol 35(4):495–516

Xiaomei Ma and Herbert Yu (2006) Global Burden of CancerYale. J Biol Med 79: (3-4):85–94

Zheying Sun (2015) The General Information of the Tumor Suppressor Gene p53 and the Protein p53 University of South Florida, USA. 3 (1)

How to Cite
Chaturvedi, I. and Tripathi, S.R. 2017. Tumor Suppressor Gene p53 (mt) Expression in Mancozeb treated Mouse Liver. Journal of Biological Sciences and Medicine. 3, 1 (Mar. 2017), 5-9.
Research Articles