Histone Modifications by different histone modifiers: insights into histone writers and erasers during chromatin modification


  • Rakesh Srivastava Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Ansan, Republic of Korea
  • Uma Meshwar Singh International Rice Research Institute (IRRI), South Asia Hub, ICRISAT, Patancheru, Telangana, India
  • Neeraj Kumar Dubey Department of Biotechnology, Central University of Rajasthan, Ajmer, Rajasthan, India


A major mechanism regulating eukaryotic cell gene expression is dynamic DNA packaging into strings of nucleosomes. Nucleosomes and their histone components are usually identified as a negative regulatory to gene transcription. The complex regulation of chromatin structure and nucleosome assembly directs accessibility of the RNA polymerase II transcription machinery to DNA that consequently leads to gene transcription. Post-translational modifications of histone proteins are central to the regulation of chromatin structure, playing essential functions in modulating the activation and repression of gene transcription. This review highlights the different types of histone modifications and their different types of modifiers that influence chromatin structure during transcription. 


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