Alpha tocopherol: Exploring the link with Oxidative stress, Smokeless tobacco and Periodontal Disease
Background: Alpha tocopherol (vitamin E) is a radical-scavenging antioxidant that protect the cells from reactive oxygen species (ROS). Increased ROS production causes oxidative stress. The effects of smokeless tobacco on periodontal disease have fewer consideration. Taking this into concern the present study was designed to determine both saliva and serum alpha-tocopherol levels in periodontal health and disease. Materials and Methods: 120 individuals of age 17 to 65 years were categorized into four groups as Group I: 30 healthy (H), group II: 30 chronic periodontitis (CP), group III: 30 smoker patients with CP, group IV: 30 smokeless tobacco chewers with CP. Vitamin E levels were determined by UV-spectrophotometer (536 nm). Statistical analysis was performed by using Analysis of variance (ANOVA) and Tukeys multiple post hoc comparison test. Results: Mean vitamin E levels in saliva and serum were found highest for Group I & least in Group III. When intergroup comparison was done, the differences in the mean vitamin E concentrations in saliva were statistically significant in all except in between Group II and IV. Whereas mean serum levels were statistically significant in all except in between Group III and IV. Conclusion: Low salivary and serum level of Î±-tocopherol is indicative of oxidative stress associated with smoking and smokeless tobacco.
Keywords: Alpha tocopherol, oxidative stress, smokeless tobacco, smoking, chronic periodontitis.
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