Overiectomized Model (Shyam Operated) and Femur Evaluation Parameters for the screening of antiosteoporotic Activity
Abstract
The objective of the present study was to perform the ovariectomy in experimental animals and to study femur evaluation parameter for antiosteoporotic activity. Ovariectomy or Sham operations were performed on Wistar albino rats under the ketamine anesthesia. Ovariectomy means removal of ovaries by surgical procedure. Changes in femur physical parameters like Femur wet weight, Femur length, Femur volume and Femur density due to the removal of the ovary in the rat were studied. Ovariectomy was successfully performed in albino wistar rats and femur evaluation parameters were studied. Ovariectomized model is a promising model to induce the osteoporosis condition similar to postmenopausal women and major bones are getting affected due to lack of estrogen.
References
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Kalu DN, Hardin RR (1984) Evaluation of the Pathogenesis of Skeletal Changes in Ovariectomized Rats. J Endocrinol 115(2):507-512
Miller SC, Miller MA, Omura TH (1988) Dietary lactose improves Endochondral growth and Bone development and Mineralization in Rats fed a Vitamin D- deficient diet. J Nutr 118:72-77. doi: 10.1093/jn/118.1.72
Peak WA, Burckhardt P, Christiansen C (1993) Consensus development conference diagnosis, prophylaxis and treatment of osteoporosis. Am J Med 94(6):646-650
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Rao JP, Bullard TR (1974) The Effect of Calcitonin on Disuse Osteoporosis in Young Rats. Ind J Med Res 62(12):1906-1909
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Stevenson JC (2005) Justification for the use of HRT in the long-term prevention of osteoporosis. 51(2):113-126. doi: 10.1016/j.maturitas.2005.01.012
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Torgerson DJ, Bell-Syer SE (2001) Hormone replacement therapy and prevention of non-vertebral fractures: a meta-analysis of randomized trials. J Am Med Assoc 285(22):2891-2897. doi: 10.1001/jama.285.22.2891
Yan Zhang (2007) Anti-osteoporotic effect of Erythrina variegata L. in ovariectomized rats. J Ethnopharmacol 109:165–169. doi: 10.1016/j.jep.2006.07.005
Yongzhong Z, Longjiang Y, Mingzhan A, Wenwen (2006) Effect of ethanol extract of Lepidium meyenii Walp On osteoporosis in ovariectomized rat. J Ethnopharmacol 105:274–279. doi: 10.1016/j.jep.2005.12.013
Zhen-Guo (2009) The osteoprotective effect of Radix Dipsaci extract in ovariectomized rats. J Ethnopharmacol 123:74–81. doi: 10.1016/j.jep.2009.02.025
Burger H, Van Daele PL, Algra D (1994) Vertebral deformities as a prediction of nonvertebral fractures. Br J Med 309:91-992
Donahue HJ, Mazzeo RS, Horvath SM (1988) Endurance Training and Bone Loss in Calcium-Deficient and Ovariectomized Rats. Metabolism 37(8):741-744
Frost HM (1992) The role of changes in mechanical usage set points in the pathogenesis of osteoporosis. J Bone and Min Res 7(3):253-261
Gass R (2001) The early preclinical diagnosis of osteoporosis measuring the pure trabecular bone density. Eur J Med Res 6(5):228-30
Goldfrank D, Haytoglu T, Frishman WH, Mohammad Z (1999) Raloxifene, a new selective estrogen receptor modulator. J Clin Pharmacol 39:767-774. doi: 10.1038/bjp.2008.262
Guyton AC, Hall JE (2006) Textbook of Medical Physiology. Elsevier, New Delhi 978-994
Islam N, Ghosh TK, Mitra C, Chanda S (1998) Cold stress facilitates Calcium Mobilization from Bone in an Ovariectomized Rat Model of Osteoporosis. J Physiol 48:49-55
Junko MO, Yoko OH, Hideyuki Y, Hiroyuki Y (2004) Pomegranate extract improves a depressive state and bone properties in menopausal syndrome model ovariectomized mice. J Ethnopharmacol 92:93–101. doi: 10.1016/j.jep.2004.02.006
Kalu DN, Hardin RR (1984) Evaluation of the Pathogenesis of Skeletal Changes in Ovariectomized Rats. J Endocrinol 115(2):507-512
Miller SC, Miller MA, Omura TH (1988) Dietary lactose improves Endochondral growth and Bone development and Mineralization in Rats fed a Vitamin D- deficient diet. J Nutr 118:72-77. doi: 10.1093/jn/118.1.72
Peak WA, Burckhardt P, Christiansen C (1993) Consensus development conference diagnosis, prophylaxis and treatment of osteoporosis. Am J Med 94(6):646-650
Prabhakara RN, Lakshmana M (2003) Prevention of bone loss in calcium-deficient ovariectomized rats by OST-6, an herbal preparation. J Ethnopharmacol 84:259-264. doi: 10.1016/S0378-8741(02)00325-2
Rao JP, Bullard TR (1974) The Effect of Calcitonin on Disuse Osteoporosis in Young Rats. Ind J Med Res 62(12):1906-1909
Riggs BL, Melton LJ (1986) Involutional Osteoporosis. N Eng J Med 314(26):1676-1686. doi: 10.1056/NEJM198606263142605
Shirwaikar A, Khanb S, Malinib S (2003) Antiosteoporotic effect of ethanol extracts of Cissus quadrangularis Linn. On Ovariectomized Rat. J Ethnopharmacol 89(2-3):245-250
Stevenson JC (2005) Justification for the use of HRT in the long-term prevention of osteoporosis. 51(2):113-126. doi: 10.1016/j.maturitas.2005.01.012
Stevensson J, Lall S, Romer J, Dickson SL, Jansson JO, Ohlsson C (2000) The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats. J Endocrinol 165:69-577. doi: 10.1677/joe.0.1650569
Torgerson DJ, Bell-Syer SE (2001) Hormone replacement therapy and prevention of non-vertebral fractures: a meta-analysis of randomized trials. J Am Med Assoc 285(22):2891-2897. doi: 10.1001/jama.285.22.2891
Yan Zhang (2007) Anti-osteoporotic effect of Erythrina variegata L. in ovariectomized rats. J Ethnopharmacol 109:165–169. doi: 10.1016/j.jep.2006.07.005
Yongzhong Z, Longjiang Y, Mingzhan A, Wenwen (2006) Effect of ethanol extract of Lepidium meyenii Walp On osteoporosis in ovariectomized rat. J Ethnopharmacol 105:274–279. doi: 10.1016/j.jep.2005.12.013
Zhen-Guo (2009) The osteoprotective effect of Radix Dipsaci extract in ovariectomized rats. J Ethnopharmacol 123:74–81. doi: 10.1016/j.jep.2009.02.025
Published
2018-06-30
How to Cite
[1]
Gunjegaonkar, S., Shukla, S., Shirsath, A. and Wankhede, S. 2018. Overiectomized Model (Shyam Operated) and Femur Evaluation Parameters for the screening of antiosteoporotic Activity. Journal of Biological Sciences and Medicine. 4, 2 (Jun. 2018).
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Research Articles
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