Overiectomized Model (Shyam Operated) and Femur Evaluation Parameters for the screening of antiosteoporotic Activity

  • S M Gunjegaonkar Department of Pharmacology, JSPM’s Charak College of Pharmacy and Research Wagholi, Pune, Maharashtra
  • S S Shukla Department of Pharmacology, JSPM’s Charak College of Pharmacy and Research Wagholi, Pune, Maharashtra
  • A Shirsath Department of Pharmaceutics, JSPM’s Charak College of Pharmacy and Research Wagholi, Pune, Maharashtra
  • S B Wankhede Department of Pharmaceutical Chemistry, JSPM’s Charak College of Pharmacy and Research Wagholi, Pune, Maharashtra

Abstract

The objective of the present study was to perform the ovariectomy in experimental animals and to study femur evaluation parameter for antiosteoporotic activity. Ovariectomy or Sham operations were performed on Wistar albino rats under the ketamine anesthesia. Ovariectomy means removal of ovaries by surgical procedure. Changes in femur physical parameters like Femur wet weight, Femur length, Femur volume and Femur density due to the removal of the ovary in the rat were studied. Ovariectomy was successfully performed in albino wistar rats and femur evaluation parameters were studied. Ovariectomized model is a promising model to induce the osteoporosis condition similar to postmenopausal women and major bones are getting affected due to lack of estrogen.

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Published
2018-06-30
How to Cite
[1]
Gunjegaonkar, S., Shukla, S., Shirsath, A. and Wankhede, S. 2018. Overiectomized Model (Shyam Operated) and Femur Evaluation Parameters for the screening of antiosteoporotic Activity. Journal of Biological Sciences and Medicine. 4, 2 (Jun. 2018).
Section
Research Articles