Study of Titanium nanoparticles in biological system using different techniques
Nanotechnology is a promising field of science and technology that deals with the effects of engineered or manufactured nanomaterial and their applications on living organisms. In addition to toxicity evaluation, these particles were characterized by different techniques like transmission electron microscopy (TEM) and nanoparticle tracking analysis (NTA). Titanium nanoparticle was within the small nanometer size range when dispersed in pure water. The particles were tended to agglomerate in media with higher ionic strength. The assessments of cytotoxicity showed that Ti nanoparticles caused a significant lessening in membrane integrity and cellular metabolic activity in a concentration dependent manner. The current study shows that size of Titanium nanoparticles and their ionic strength is adequate and also can be used at low concentrations to determine adverse effect in further studies.
Baan RA (2007) Carcinogenic hazards from inhaled carbon black, titanium dioxide, and talc not containing asbestos or asbestiform fibers: recent evaluations by an IARC Monographs Working Group. Inhal Toxicol 19:213–228
Bermudez E, Mangum JB, Wong BA, Asgharian B, Hext PM, Warheit DB, Everitt JI (2004) Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicol Sci 77:347–357
Berne BJ and Pecora R (1975) Dynamic Light Scattering. John Wiley, New York
Demir E, Kaya N, Kaya B (2014) Genotoxic effects of zinc oxide and titanium dioxide nanoparticles on root meristem cells of allium cepa by comet assay. Turk J Biol 38:31-39
Domingos RF, Baalousha MA, Ju-Nam Y (2008) Characterizing manufactured nanoparticles in the environment: Multi method determination of particle sizes. Environ. Sci Technol 43 (19):7277–7284
Drexler K Eric (1986) Engines of Creation: The Coming Era of Nanotechnology. Doubleday. ISBN 0-385-19973-2
Gontier E, Ynsa MD, Bíró T, Hunyadi J, Kiss B, Gáspár K, Pinheiro T, Silva JN, Filipe P, StachuraJ, Dabros W, Reinert T, Butz T, Moretto P, Surlève Bazeille, JE (2008) Is there penetration of titania nanoparticles in sunscreens through skin? A comparative electron and ion microscopy study. Nanotoxicol 22:18–231
Hubler A (2010) "Digital quantum batteries: Energy and information storage in nanovacuum tube arrays". Complexity. doi:10.1002/cplx.20306
Gopinath V, Mubarak Ali D, Priyadarshini S, Priyadharsshini NM, Thajuddin N, Velusamy P (2012) Biosynthesis of silver nanoparticles from Tribulus terrestris and its antimicrobial activity: a novel biological approach. Colloids and Surfaces, B: Biointerfaces 96:69-74
Kashiwada S (2006) Distribution of Nanoparticles in the See-through Medaka (Oryzias latipes). Environ Health Perspect 114(11):1697–1702
Lyon D (2013) Gap size dependence of the dielectric strength in nano vacuum gaps. IEEE. doi:10.1109/TDEI.2013.6571470
Murdock RC, Laura Braydich-Stolle AM, Schrand John J, Schlager Saber M Hussain (2008) Characterization of Nanomaterial Dispersion in Solution Prior to In Vitro Exposure Using Dynamic Light Scattering Technique. Toxicol Sci 101:239–253
Natarajan K, Selvaraj S, Ramachandra MV (2010) Microbial production of silver nanoparticles. J Nanomat Biostruct 5:135-140
Parthsarthi A and Thilagavthi G (2009) Synthesis and characterization of titanium dioxide nano particles and their applications to textiles for microbe resistance. J Text Apparel Technol Management 6:2-2009
Park HG (2012) Gene expression in zebra fish embryos following exposure to Cu-doped TiO2 and pure TiO2 nanometer-sized photocatalysts. Mol Cell Toxicol 8:127–137
Powers K, Brown S, Krishna V, Wasdo S, Moudgil B, and Roberts S (2006) Research strategies for safety evaluation of nanomaterials. Part VI. Characterization of nanoscale particles for toxicological evaluation. Toxicol Sci 90:296–303
Rahman Q, Lohani M, Dopp E (2002) Evidence that ultrafi ne titanium dioxide induces micronuclei and apoptosis in Syrian hamster embryo fibroblasts. Environ Health Perspect 110:797–800
Saini R, Saini S, Sharma S (2010) "Nanotechnology: The Future Medicine". Journal of Cutaneous and Aesthetic Surgery. 3 (1):32–33
Simakov S and Tsur Y (2006) Surface stabilization of nano-sized titanium dioxide: improving the colloidal stability and the sintering morphology. J Nanopart Res 9:403–417
Trouiller B, Reliene R, Westbrook A, Solaimani P, Schiesti RH (2009) Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice. Cancer Res 69:8784–8789
Umme, T (2011) Synthesis and characterization of silver nanoparticles by chemical reduction method. Nano science, Engineering and Technology (ICONSET), International Conference
Williams D, Ehrman S, and Holoman T (2006) Evaluation of the microbial growth response to inorganic nanoparticles. J. Nanobiotechnol. doi: 10.1186/1477-3155-4-3
Wu Y, Yang W, Wang C, Hu J, Fu S (2005) Chitosan Nanoparticles as a novel delivery system for ammonium glycyrrhizinate. Int J Pharm 295:235–245
Yeo MK, Kang M (2009) Effects of CuxTiOy nanometer particles on biological toxic during zebrafish embryogenesis. Korean J Chem Eng 26:711-718
Copyright (c) 2017 Gupta et al.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).