Alternations of selenium and malondialdehyde status in chronic kidney disease
Abstract
Chronic kidney disease (CKD) is a major public health burden worldwide. CKD patients have cardiovascular risk factors such as diabetic mellitus and hypertension. These factors are associated with oxidative stress which accelerates renal injury in CKD patients. This study aimed to determine selenium (antioxidant trace element) and malondialdehyde (MDA, oxidative stress marker) in patients with CKD. Serum selenium and MDA levels are analyzed in CKD patients (n=20) compared with values observed in control (n=20). Serum urea, creatinine and MDA levels were determined with spectrophometric methods and serum selenium level was measured by atomic absorption spectrophotometry. Serum selenium and MDA in CKD patients showed significant differences in comparison with control – MDA 2.42 ± 0.57 vs. 0.98 ± 0.09 µmol/L (p<0.001) and selenium 81.52 ± 10.24 vs. 105.46 ± 10.53 µg/L (p<0.001). A significant negative correlation was observed between serum selenium and MDA in CKD patients (r = - 0.88, p < 0.0001), while there was a significant positive correlation of selenium level with creatinine clearance in CKD (r = 0.714, p <0.001). There is imbalance between oxidative stress and antioxidant status in CKD. We suggest MDA could be used as oxidative marker for progressive kidney diseases.
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